Motorists are being advised that the A8 Belfast - Larne Road will be closed to traffic at the Green Road junction overnight on October 7 and 8.
Contractors Lagan Ferrovial Costain have confirmed that the night time closures at the Green Road interchange will take place on both dates between 11.45pm and 6am.
The route will be closed to ensure the safety of workers and road users while massive concrete bridge beams are lifted into place.
Two further overnight road closures on the A8, for bridge beam lifts at the Moss Road interchange, are expected to take place next month.
A series of other road closures, including at Calhame Road, Lismenary Road, Hillhead Road, Ballyrickard Road and Shaneshill Road, are scheduled to take place next year.